Brochure Fillers - Flipbook - Page 13
Neauvia’s R&D designed monophasic and
PEGDE crosslinking presents different molecular
cohesive hydrogels with distinctive properties
weights and different chain lengths.
and gel consistencies.
High conformational flexibility
Neauvia PEG-HA Fillers are based on a unique
Shape modification without structural damage
patented Smart Crosslinking Technology (SXT)
which is an innovative and advanced technology
These characteristics influence how the product
that combines Hyaluronic Acid and PEGDE
behaves under the mechanical stress during the
in one network.
injection phase and during its life in the tissues.
HYAL CHAINS
Hyaluronic Acid
PEGDE
PEGDE
AS CROSSLINKER
HYAL CHAINS
Illustrative bi-dimensional rendering of the hydrogel matrix.
*None detected so far with the use of Neauvia PEG-HA Fillers.
1. Marino F, Cosentino M, Legnaro M, Luini A, Sigova J, Mocchi R, Lotti T and Zerbinati N. Immune profile of Hyaluronic Acid hydrogel Polyethylene Glycol crosslinked:
an in vitro evaluation in human polymorphonuclear leukocytes. Dermatologic Therapy. 2020; e13388. https://doi.org/10.1111/dth.1338
2. Jeong CH, Kim DH, Yune JH, Kwon HC, Shin DM, Sohn H, Lee KH, Choi B, Kim ES, Kang JH, Kim EK and Han SG. In vitro toxicity assessment of crosslinking agents used
in Hyaluronic Acid dermal filler. Toxicology in Vitro, Volume 70, 2021, 105034, ISSN 0887-2333. https://doi.org/10.1016/j.tiv.2020.105034
3. Clinical data on file.
4. Zerbinati N, Lotti T, Monticelli D, Rauso R, González-Isaza P, D’Este E, Calligaro A, Sommatis S, Maccario C, Mocchi R, Lotti J, Wollina U, Tchernev G and França K.
In vitro evaluation of the biosafety of Hyaluronic Acid PEG cross-linked with micromolecules of Calcium Hydroxyapatite in low concentration. Open Access Maced J Med Sci.
https://doi.org/10.3889/oamjms.2018.044
5. Zerbinati N, Lotti T, Monticelli D, Martina V, Cipolla G, D’Este E, Calligaro A, Mocchi R, Maccario C, Sommatis S, Lotti J, Wollina U, Tchernev G and França K. In vitro evaluation
of the sensitivity of a Hyaluronic Acid PEG cross-linked to bovine testes Hyaluronidase. Open Access Maced J Med Sci. https://doi.org/10.3889/oamjms.2018.046
6. Zerbinati N, Capillo MC, Sommatis S, Maccario C, Alonci G, Rauso R, Galadari H, Guida S and Mocchi R. Rheological investigation as tool to assess physicochemical stability
of a Hyaluronic Acid dermal filler cross-linked with Polyethylene Glycol Diglycidyl Ether and containing Calcium Hydroxyapatite, Glycine and L-Proline. Gels 2022, 8,
264. https://doi.org/10.3390/gels8050264
7. Zerbinati N, Sommatis S, Maccario C, Capillo MC, Grimaldi G, Alonci G, Protasoni M, Rauso R and Mocchi R. Toward physicochemical and rheological characterization
of different HA dermal fillers cross-linked with Polyethylene Glycol Diglycidyl Ether. Polymers 2021, 13, 948. https://doi.org/10.3390/polym13060948
