SCIENCE-BOOK 29.04.2025 - Flipbook - Page 7
FILLERS
Safety pro昀椀le
Summary of the publication:
03
Lip augmentation with hyaluronic acid hydrogel crosslinked with polyethylene glycol diglycidyl ether (PEGDE)
in two women with autoimmune disease. Case report
Authors: Mustafa N. O. I Published on 14.02.2024
INTRODUCTION
This study aimed to present the results of lip augmentation using a 24 mg/ml hyaluronic
acid hydrogel cross-linked with polyethylene glycol diglycidyl ether (PEGDE)
supplemented with l-proline and glycine to reduce post-injection swelling. The article
presents a retrospective study of two women following lip augmentation diagnosed
with an autoimmune disease: one with systemic lupus erythematosus and the other
with multiple sclerosis.
RESULTS
Woman 1 - a 22-year-old female with SLE treated previously with BDDE-HA,
received PEGDE-HA: 0.7 ml initially, 0.3 ml after 3 weeks. Woman 2 - a
23-year-old female with MS and no prior filler treatments, received PEGDE-HA:
0.9 ml initially, 0.1 ml after 1 week.
In both cases, PEGDE-HA was injected in a total amount of 1 ml.
Local anesthesia was used.
After the first injection, both patients reported no noticeable lumps or bumps;
lips were neither sensitive nor painful.
After the second session, both women reported no bruising or swelling and
remained satisfied. No adverse events were observed.
Fig.1: Woman 1 - before and after the second session, 3 weeks after the initial treatment Source: Own study
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Fig. 2: Woman 1 - before and 3 months after the initial treatment Source: Own study
KEY MESSAGES
Despite autoimmune diseases (SLE and MS), both women safely underwent lip
augmentation with PEGDE-crosslinked HA filler.
No inflammatory reactions, granulomas, or complications were observed
during or after treatment.
PEGDE-HA may be a safe and effective option for aesthetic procedures in
autoimmune patients, though further observation is needed.
CONCLUSION
In the presented case report PEGDE-HA was effective for volume augmentation
of the lips, and well tolerated with no adverse events reported. Natural results were
achieved even with a small amount of filler used, and both subject and doctor
satisfaction was high.
The choice of HA fillers cross-linked with PEG should be considered safe in the
case of women suffering from SLE (systemic lupus erythematosus) and MS (multiple
sclerosis). Of course, extreme caution should always be exercised when offering
treatment to patients suffering from autoimmune diseases, and followed by
manufacturers’ recommendations.
Reference: Mustafa NO. Lip augmentation with hyaluronic acid hydrogel cross-linked with polyethylene glycol diglycidyl ether (PEGDE)
in two women with autoimmune disease. Case report. Aesth Cosmetol Med. 2024;13(2):77-81. https://doi.org/10.52336/acm.2024.013.
