SCIENCE-BOOK 29.04.2025 - Flipbook - Page 7
FILLERS
Safety profile
Summary of the publication:
In Vitro Evaluation of the Biological Availability
of Hyaluronic Acid Polyethylene Glycols-Cross-Linked
Hydrogels to Bovine Testes Hyaluronidase
KEY MESSAGES
Authors: Zerbinati N. et al. I Published on 12.06.2019
Very low risk of granulomatous reaction and associated cellulitic processes.
Neauvia gel carries a very low risk of immune-mediated adverse effects.
Neauvia gel does not carry signicant risks of pro inflammatory effects.
INTRODUCTION
The aim of this study was to assess different fillers in HA content and PEGDE
concentration in vitro, in terms of their degree of being susceptible
to hyaluroni- dase and the influence on their biocompatibility.
The colorimetric determination of the N-acetyl-D-glucosamine (NAG)*
still present in solution after incubation with hyaluronidase, at different time
points, determined the product degradation.
CONCLUSION
This article shows that Neauvia gel does not carry significant risks
of pro-inflammatory effects on PMN, but also that it can effectively modulate
PMN functions resulting in anti-inflammatory activities.
RESULTS
The tested products (Neauvia Intense Rheology, Neauvia Intense Lips,
Neauvia Intense LV, Neauvia Intense Flux, and Neauvia Stimulate)
were sensitive to hyaluronidase degradation.
Reference: Zerbinati N, Mocchi R, Galadari H, Maccario C, Maggi M, Rauso R, Passi A, Esposito C, Sommatis S. In Vitro Evaluation of the
Biological Availability of Hyaluronic Acid Polyethylene Glycols-Cross-Linked Hydrogels to Bovine Testes Hyaluronidase. Biomed Res Int.
2019 Jun 12;2019:3196723. doi: 10.1155/2019/3196723. PMID: 31309104; PMCID: PMC6594335.
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