SCIENCE-BOOK 29.04.2025 - Flipbook - Page 27
MADE FOR COMBINATION
LaserMe, Fillers and Aesthetic Cosmeceuticals
Summary of the publication:
01
A combination treatment protocol using PEGylated
hyaluronic acid hydrogel, non-ablative laser and
hyaluronic acid skin boosters for rejuvenation of the
perioral area
Authors: Kroeskop A. et Voropai D. | Published on 18.12.2024
INTRODUCTION
Many factors, but in particular balanced facial proportions and good skin
condition, affect facial attractiveness and the perception of age. This is most
evident in areas of facial expression, which become the center of attention
during social interactions. In the lower face, this focus is on the mouth and
surrounding perioral area. An attractive smile creates a social perception of
happiness and youthfulness. An improvement in smile aesthetics is the main
reason adult patients seek orthodontic care and lip enhancement continues
to be one of the most requested aesthetic procedures worldwide. As the aging
process is multifactorial, perioral rejuvenation has several aims other than just
restoring lip volume. A combination of treatments, each addressing a relevant
component of the aging process, will provide synergistic benefits beyond that
which can be achieved by a single procedure.
RESULTS
Data were analyzed retrospectively for 14 female subjects with a mean age
of 39.1 years (range 32 to 45 years). At baseline, mean score for lip fullness
was 2.1 and skin wrinkling was 1.3. A total of 1 ml was injected (0.5 ml per lip).
Lip fullness improved with mean scores of 2.9 and 2.8 at Visit 1, and 3.0 at Visit
2. Mean skin wrinkle score improved from 1.3 to 0.9 at Visit 1 and 0.8 at Visit 2.
Mean GAIS scores indicated appearance was ‘improved’ at Visit 1 and
‘much improved’ at Visit 2. All patients were ‘somewhat happy’ or ‘happy’
and would be ‘likely’ or ‘very likely’ to recommend the protocol.
Back to the Sectum, Fillers and Aesthetic Cosmeceuticals page
Fig. 1: Patient images before (left image in pair)
and 12 weeks after (right image in pair) treatment
with the protocol.
KEY MESSAGES
The combination of PEGDE-HA hydrogel, non-ablative fractional laser, and HA
mesotherapy in a single session significantly improved lip fullness and perioral
skin quality.
All treatments were well tolerated with high levels of satisfaction reported by
both physicians and patients.
The 3-step protocol provides synergistic, natural-looking rejuvenation results
without reported adverse effects.
CONCLUSION
The sequence of PEGDE-HA lip rejuvenation followed by full face laser resurfacing
and HA mesotherapy treatment demonstrated effectiveness in enhancing the
perioral area’s appearance within a single session. The combination of three
complementary treatments enhanced skin quality as well as lip shape and
volume for a natural-looking, anti-aging effect. All treatments were well-tolerated,
and both physicians and patients were satisfied with the improvement in lip and
skin appearance.
Reference : Kroeskop, A. and Voropai, D. 2025. A combination treatment protocol using PEGylated hyaluronic acid hydrogel, nonablative laser and hyaluronic acid skin boosters for rejuvenation of the perioral area. Journal of Applied Cosmetology. 43, 1 (Jan. 2025),
11/20. DOI:https://doi.org/10.56609/jac.v43i1.439.
