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Summary of the publication:
01
40,
Non-crosslinked hyaluronic acid mesotherapy
and hydro-exfoliation plus infrared technology:
a combination protocol to improve skin quality
Authors: Fernández de Castro Isalguez R. et Fernandez E.M. | Published on 05.11.2024
INTRODUCTION
All patients included in this analysis attended 2 visits, spaced 1 week apart. Treatment areas
varied per patient, including the face, neck, and décolleté.
On Day 0, mesotherapy was performed with injections of noncrosslinked hyaluronic acid
(HA) (18 mg/mL) combined with 0.01% calcium hydroxyapatite, glycine, and l-proline
(Neauvia Hydro Deluxe). Multiple intradermal or subcutaneous injections (0.5 to 4 mm
depth) of small HA volumes were administered using a 30G needle and a pre-filled 2.5 ml
syringe. Local topical anesthesia was available, though not all patients required it.
On Day 7, patients underwent a hydro-exfoliation and infrared treatment of the entire face.
Hydro-exfoliation involves using accelerated microscopic droplets for deep cleansing and
hydration. The infrared component used a lamp with an inverted filter, emitting radiation
in the 700–1800 nm range. The power was constant, and energy density per pulse (J/cm2)
was operator-set, with the device adjusting pulse duration according to energy density.
The treatment involved 2-3 passes, with energy settings of 35–45 J/cm2, heating the deep
dermal layers up to 65°C based on patient sensitivity and comfort. Continuous cooling
provided surface protection throughout the procedure. The procedure was painless,
required no prior preparation, and did not necessitate local anesthesia.
RESULTS
Comparison of post-treatment with baseline images showed enhanced skin
tone and quality.
Observed changes in the face area included improvements in wrinkles (13%23%), pores (16%-30%), skin texture (15%-28%), and oiliness (10%-33%) (Fig. 1).
Patients reported a ‘glow effect’ on the treatment day. Patients indicated
that the neck, décolleté, and periocular area were the most impacted in the
weeks and months post-treatment. Reported improvements included thicker
skin sensation, reduced elastosis, and a more radiant glow.
Patients with sensitive, reactive skin and even eczema noted correction
of these conditions following the treatment protocol.
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30,
20,
12,
Front
Left
Right
0
Wrinkels
Texture
Pores
Oiliness
Brown spots
Graph 1:
Percentage improvements in face skin
qualit measures after treatment with
non- crosslinked HA followed by hydroexfoliation and infrared technology.
Results show improvement at 2 weeks after
last treatment compared with baseline
assessed with the OuantifiCare device.
KEY MESSAGES
This study evaluated a new protocol combining non-crosslinked hyaluronic
acid (HA) with hydro-exfoliation and infrared technology for improving skin
quality parameters.
Comparison of post-treatment with baseline images showed improvements in
wrinkles of 13%-23%, pores of 16%-30%, skin texture of 15%-28%, and oiliness of
10%-33%.
The combination of non-crosslinked HA mesotherapy, hydro-exfoliation,
and infrared technology led to visible improvements in several skin quality
parameters across a wide age range.
CONCLUSION
The combination of non-crosslinked HA combined with low concentration of
CaHA with hydro-exfoliation and infrared energy led to clinically significant
improvements in skin quality including reduced lines and wrinkles, pore size and
number, oiliness and improved skin texture. These changes were observed over a
range of skin types and age groups. All treatments were well tolerated and can be
safely combined to provide enhanced outcomes in face rejuvenation.
Reference: de Castro Isalguez, R.F. and Fernández, E.M. 2024. Non-crosslinked hyaluronic acid mesotherapy and hydro-exfoliation
plus infrared technology: a combination protocol to improve skin quality. Journal of Applied Cosmetology. 42, 2 (Nov. 2024), 3/12.
DOI:https://doi.org/10.56609/jac.v42i2.414.
