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MADE FOR COMBINATION
Sectum, Fillers and Aesthetic Cosmeceuticals
Combined Bipolar Radiofrequency and Non-Crosslinked
Hyaluronic Acid Mesotherapy Protocol to Improve Skin
Appearance and Epidermal Barrier Function: A Pilot Study
Authors: Płatkowska A. et al. I Published on 12.08.2023
Ultrasound
analysis
Summary of the publication:
Change in thickness of the skin
Change in density of the skin
Change in thickness of the epidermis
Change in density of the epidermis
RADIOFREQUENCY
COMBINED TREATMENT
(% Change)
(% Change)
+1,4
+5,6
-18,1
+7,1
+2,7
+12,0
+12,4
+57,7
INTRODUCTION
The aim of this pilot study was to assess the synergistic effects of a new bipolar
radiofrequency in combination with a non-crosslinked hyaluronic acid + CaHA
mesotherapy protocol compared to radiofrequency alone on skin appearance
and markers of epidermal function. The study recruited 20 female subjects, mean
age 46 years (range 29 to 54 years), with Fitzpatrick skin phototype I–IV. All women
presented with dry and lax facial skin with a TEWL (Trans-Epidermal Water Loss)
value of at least 26 g/m2/h.
The study consisted of two visits, 4 weeks apart. Patients were treated with a bipolar
radiofrequency device Sectum (Berger & Kraft Medical Sp. z o.o., Warsaw, Poland)
on both sides of the face. This was immediately followed by a treatment on one side
of the face with 2.5 ml of Neauvia Hydro Deluxe (Matex Lab, Geneva, Switzerland),
non-crosslinked hyaluronic acid (HA) wih 0.01% CaHA. Photographic documentation,
analysis of epidermal barrier function parameters, and high frequency (HF) ultrasound
analysis were performed prior to treatment and at 28 days.
Cutometer
analysis
RESULTS
Stratum corneum hydration
TEWL
Melanin
Erythema
RADIOFREQUENCY
COMBINED TREATMENT
(% Change)
(% Change)
+1,0
+3,9
-1,5
+3,0
+23
-5,8
-7,5
-7,2
KEY MESSAGES
The combined bipolar radiofrequency and HA + CAHA mesotherapy protocol
provided greater improvements in skin hydration, firmness and tone compared
with radiofrequency alone.
The combination treatment was also associated with greater epidermal
thickness and density and increased keratinocyte differentiation suggesting
a synergistic effect of the combined treatments on epidermal homeostasis
and barrier function.
Results showed clear clinical improvement of skin tightening and rhytides
on the cheeks, chin, crow’s feet and the forehead region.
CONCLUSION
Radiofrequency devices and HA + CaHA mesotherapy products represent two
separate modalities for skin rejuvenation with synergistic effects on epidermal
rejuvenation. In this split-face pilot study, a treatment protocol combining bipolar
radiofrequency with a non-crosslinked hyaluronic acid mesotherapy procedure
improved epidermal barrier function parameters including stratum corneum
hydration, TEWL, and pigmentation to a greater extent than treatment with
radiofrequency alone. Ultrasound analysis confirmed that the combined protocol
was also associated with significantly improved epidermal thickness and cell
density compared with radiofrequency alone.
Reference: Płatkowska, A.; Korzekwa, S.; Łukasik, B.; Zerbinati, N. Combined Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid
Mesotherapy Protocol to Improve Skin Appearance and Epidermal Barrier Function: A Pilot Study. Pharmaceuticals 2023, 16, 1145. https://
doi.org/10.3390/ph16081145.
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