SCIENCE-BOOK 29.04.2025 - Flipbook - Page 13
FILLERS
Volume restoration
Summary of the publication:
01
A Comparative Case Study on Echographic Behaviour
of Selected Soft Tissue Fillers
Author: Garcerant Tafur M. I Published on 17.04.2025
INTRODUCTION
This split-face case series included a total of 9 female patients, divided into 3 groups,
with the aim of evaluating and comparing the echographic behaviour and volumetric
persistence of soft tissue fillers based on different formulations of hyaluronic acid (HA)
and/or calcium hydroxylapatite (CaHA). The participants’ ages ranged from 30 to 68
years at the time of treatment.
The following filler products were used in the study:
- PEGDE-HA28 (Matex Lab, Geneva, Switzerland)
- PEGDE-HA26 + CaHA (Matex Lab, Geneva, Switzerland)
- BDDE-HA25 (Allergan, Dublin, Ireland)
- BDDE-HA + CaHA (Allergan, Dublin, Ireland)
- CaHA + CMC (Merz Aesthetics, Raleigh, NC, USA)
The injection protocol was standardized across all groups to ensure consistency
and comparability. Each patient received 0.5 ml of filler per side, administered
subcutaneously into the zygomatic arch region, in accordance with the
manufacturers’ guidelines and indications. All injections were performed using a sterile
22 G cannula via a 21 G needle entry point, with bilateral symmetry in volume and
technique maintained across treatments.
RESULTS
The projection achieved 6 months after administering 0.5 ml of tissue filler per
side ranged from 1.33 mm for CaHA+CMC to 12.67 mm for PEGDE-HA 28 and
PEGDE-HA 26 + CaHA.
The volumetric effect observed 6 months after administering all fillers ranged
from 0.20 ml to 0.63 ml, respectively for BDDE-HA+CaHA and PEGDE-HA
26+CaHA.
The reduction in SLEB following treatment with PEGDE-based fillers may
therefore signify an anti-aging effect, as the fillers could potentially improve
skin hydration, restore dermal structure, and enhance overall skin quality.
The role of PEGDE-based fillers in reducing SLEB thickness might be indicative
of their ability to restore or mimic the properties of younger skin, particularly
by addressing the underlying issues of skin laxity and elastosis.
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Table 1a: Changes in volume, projection at 1, 3, and 6 months after the injection.
Table 1b: Changes in SLEB thickness at 1, 3, and 6 months after the injection.
KEY MESSAGES
PEGde-ha-based fillers demonstrated more homogeneous tissue integration,
with less edema and irregularity on ultrasound compared to monophasic or
biphasic ha fillers.
The observed evolution of SLEB showed a marked reduction in the thickness
and echogenicity of the subepidermal low-echogenic band (SLEB) in
participants treated with PEGDE-crosslinked fillers.
Adding CaHA to PEGDE-HA may enhance its ability to stimulate collagen and
improve dermal structure.
CONCLUSION
All participants completed the study and demonstrated clear aesthetic
improvement after receiving fillers in the zygomatic arch area. Patients anticipate
an increase in volume and aesthetic effect, with neocollagenesis being one of the
expected outcomes of tissue revitalization treatments following the administration
of these types of preparations. High-frequency ultrasound also provides noninvasive insights into the behaviour of products administered by the physician,
enabling the prediction of their effects. The images from HF-USG indicate that all
soft tissue fillers are safe and effective in restoring lost volume.
Reference : Garcerant Tafur, M. 2025. A Comparative Case Study on Echographic Behaviour of Selected Soft Tissue Fillers. Journal of
Applied Cosmetology. 43, 2 (May 2025), Ahead of print. DOI:https://doi.org/10.56609/jac.v43i2.508.
