SCIENCE-BOOK 29.04.2025 - Flipbook - Page 11
FILLERS
Rheological properties
Summary of the publication:
Heat Influence on Different Hyaluronic Acid Fillers
Authors: Kubik P. & Gruszczyński W. I Published on 25.10.2023
INTRODUCTION
Before (cm2)
After (cm2)
Change (%)
20 mg/ml BDDE I
1,663
1,715
3,1
25 mg/ml BDDE II
1,142
1,188
4,0
28 mg/ml PEG
1,502
1,502
0,0
Table 1: Results of heating of HA samples (20-mg/ml HA-BDDE; 25-mg/ml HA-BDDE; 28 mg/ml HA-PEG).
The objective of this study was to determine the characteristics of HA gels in terms
of heat resistance. Five types of HA fillers, chosen from most common products
on the market for the temporary correction of congenital and acquired soft tissue
deficits of the face through intradermal or subcutaneous Injection.
Four dermal fillers crosslinked BDDE (20mg/ml HA-BDDE, 20mg/ml HA-BDDE, 20mg/ml
HA-BDDE, 25 mg/ml HA-BDDE) and one product crosslinked with PEG (28mg/ml
HA-PEG) were tested in this study.
The temperatures used during this test correspond with commonly used heat-based
devices, such as radio-frequency devices (about 45°C), infrared (about 55-65°C)
and HiFU (about 70-75°C).
Heat degradation of the HA samples was measured as a change of the surface area
of the samples (graph paper and graphing program for area calculation)
RESULTS
The 28mg/ml HA-PEG filler demonstrated greater resistance to heat versus
the 20mg/ml and 25mg/ml BDDE fillers.
The 28mg/ml HA-PEG filler demonstrated greater resistance to heat in terms
of deformation / thermal degradation and change of surface area in both
test (celltibator with/without rotation and autoclave).
As shown in Tables I and II during the test proceeded in the celltibator (temp.
55,2°C) with and without centrifuging, change of surface area of the samples
was observed. In case of the combined test – heating and centrifuging
for the sample of 20 mg/ml HA-BDDE gel, the degradation was significant.
Before (cm2)
After (cm2)
Change (%)
20 mg/ml BDDE I
1,155
1,500
29,9
28 mg/ml PEG
1,309
1,366
4,3
Table 2: Results of heating and centrifuging of HA samples (20-mg/ml HA-BDDE and 28- mg/ml HA-PEG).
KEY MESSAGES
The heat resistance of HA fillers is crosslinking agent depended.
Selection of dermal fillers is crucial in case of using IR, RF, HiFU (or any other
heat emitting device) over the injected filler.
All tested products were sensitive to heat degradation, but the degradation
percentage obtained in the experimental conditions was much lower for HA
filler crosslinked with polyethylene glycol diglycidyl ether (PEGDE).
CONCLUSION
Clinical outcomes of this article shows that the choice of dermal filler when
combining different technologies, especially a heat emitting device, can be a
key factor in achieving a natural-looking, safe, long-lasting desired aesthetic
result. The study results showed that all the tested products were sensitive to heat
degradation, but the degradation percentage obtained in the experimental
conditions was much lower for HA filler crosslinked with polyethylene glycol
diglycidyl ether (PEGDE).
Reference: Kubik, P. and Gruszczyński, W. 2023. Heat Influence on Different Hyaluronic Acid Fillers. Journal of Applied Cosmetology. 41, 2
(Nov. 2023), ahead of print. DOI: https://doi.org/10.56609/jac.v41i2.305.
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